Just Like Wine…

May 22, 2009

Older Population Might Have Immunity to H1N1 Swine Flu

Older adults might have some pre-existing immunity to the 2009 H1N1 (swine) flu virus, according to the CDC.

Serological tests showed that some adults, particularly those over 60, had antibodies effective against the new strain, Jacqueline Katz, Ph.D., of the influenza division of the CDC’s National Center for Immunization and Respiratory Diseases, and colleagues wrote in the May 22 issue of Morbidity and Mortality Weekly Report.

But Anne Schuchat, M.D., interim deputy director for the CDC’s science and public health programs, cautioned against reading too much into the finding.

“We don’t know yet what that will mean in terms of actual immunity or clinical protection,” she said on a conference call with reporters.

As the worldwide H1N1 flu outbreak progresses, epidemiological evidence continues to point to a disproportionate number of infections in school-age children and younger adults.

Of the cases reported to the CDC, 64% are in 5- to 24-year-olds and just 1% are in individuals older than 65, an unusual pattern compared with seasonal influenza.

This has led to speculation that older individuals have at least some degree of pre-existing immunity, possibly from years of immunization with seasonal flu vaccines. They contained different H1N1 viruses than the current outbreak strain, or previous infection.

“The study we’re reporting today provides a little clue that’s consistent with that clinical observation,” Dr. Schuchat said.

She noted, however, that genetic testing has found that the new H1N1 virus is not a close relative to any of the other H1N1 viruses that have circulated among people.

The tests also confirmed that seasonal flu vaccine is likely to have “little or no immune benefit” in protecting against the new virus, as many researchers had suspected.

Seasonal vaccines from the past four flu seasons induced some cross-reactive antibody response to the new virus, but probably not enough to stave off infection.

“CDC does not believe that seasonal influenza vaccine would provide any meaningful protection against this novel H1N1 strain,” Dr. Schuchat said.

Agency researchers analyzed 359 stored serum samples from individuals ranging from 6 months to 64 years, before and after vaccination during flu seasons since 2005-2006. The samples were obtained during U.S. and European vaccine studies.

Both before and after vaccination, children up to 9 years had no level of cross-reactive antibody to the new virus.

Before vaccination, in up to 9% of adults ages 18 to 64, and in 33% of those older than 60, cross-reactive antibody to the new H1N1 virus was present at levels that have been associated with a 50% reduction in the risk of influenza infection or disease.

This pre-existing immunity possibly results from previous exposure to H1N1 viruses more similar to the new virus than to current seasonal H1N1 viruses — either through vaccination or infection.

After receiving a seasonal flu shot, up to 25% of 18- to 64-year-olds and 43% of individuals over 60 had cross-reactive antibody to the new virus.

Dr. Schuchat discounted the apparent booster effect following vaccination, noting that the results were based on a relatively small number of specimens and an unconventional test of antibody response to influenza.

Share This:
  • Digg
  • Facebook
  • Twitter
  • Technorati
  • LinkedIn

Free Drugs for A Year to Unemployed

May 15, 2009

Pfizer Offers Year of Free Meds to Unemployed

Drug giant Pfizer said unemployed people who have been taking its branded products could receive them free for up to a year in a new program — with some exceptions.

The program, called MAINTAIN, will provide access to more than 70 Pfizer drugs including atorvastatin (Lipitor), celecoxib (Celebrex), pregabalin (Lyrica), and sildenafil (Viagra).

But the program excludes biologics, most cancer drugs, and other of Pfizer’s most expensive products.

Individuals who became unemployed after Jan. 1 of this year are eligible for the program and may sign up through Dec. 31.

Other eligibility requirements include having taken the branded Pfizer drug for at least three months prior to losing a job, having no other prescription drug coverage, and being able to attest to financial hardship.

Income prior to becoming unemployed is not a factor, Pfizer said. But participants who regain employment or prescription drug coverage will have to start paying again.

A stock analyst quoted by the Associated Press pointed out that the program is likely to prevent some current Pfizer drug customers from switching to generic equivalents.

The company said it was taking signups today, although the program would not be fully operational until July 1.

Pfizer said signups and additional information on the MAINTAIN program would be available at Pfizer Helpful Answers or by calling 866-706-2400 toll-free.

Share This:
  • Digg
  • Facebook
  • Twitter
  • Technorati
  • LinkedIn

Containing the Swine Flu

May 13, 2009

Europe Tries to Contain H1N1 Flu With Drugs

In an effort to contain the H1N1 (swine) flu outbreak, European countries are using antiviral drugs “very aggressively” to prevent transmission, a World Health Organization official said.

But WHO is cautioning that most cases of the disease appear to be mild ones that won’t need hospital care or antivirals, according to Nikki Shindo, M.D., who leads the agency’s clinical team that’s responding to the outbreak.

Dr. Shindo added that there’s no evidence yet of how well the medications — oseltamivir (Tamiflu) and zanamivir (Relenza) — work against the novel H1N1 strain.

In contrast, in the U.S. and Mexico — where the H1N1 outbreak can no longer be contained — officials are using antivirals mainly for treatment of people in high-risk groups or who have severe disease.

“The circumstance in the U.S. are very different from the circumstances in a number of European countries,” according to Anne Schuchat, M.D., of the CDC’s Science and Public Health Program.

“We don’t have a situation where we can contain the virus’s geographic distribution, and our focus is on reducing illness and death and mitigating the impact this virus has,” Dr. Schuchat said.

The priority for antiviral drugs is “where we think the treatment will make a difference,” she added.

Share This:
  • Digg
  • Facebook
  • Twitter
  • Technorati
  • LinkedIn

chicago evanston top 100 personal injury attorneys
chicago evanston million dollar advocate personal injury attorneys
chicago evanston personal injury law guru attorneys

evanston chicago personal injury attorneys testimonials

“I just wanted to say hello and a BIG thanks to you for what you did for me. It was a year ago, that I got the settlement, and I’m still stunned at what transpired… and so quickly.”J.A.